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peptide comparison · metabolic

Retatrutide vs Tirzepatide

Two compounds, mechanism by mechanism. Where they overlap, where they don't, and which vendors stock each.

§ 01

Mechanism

retatrutide

Retatrutide

LY3437943GLP-3triple-G

Triple agonist of GLP-1, GIP, and glucagon receptors. Eli Lilly's Phase 3 candidate (TRIUMPH program).

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vs
tirzepatide

Tirzepatide

MounjaroZepbound

Dual GLP-1 / GIP receptor agonist. FDA-approved as Mounjaro (T2D) and Zepbound (obesity).

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§ 02

Key facts

factRetatrutideTirzepatide
category
·metabolicmetabolic·
half-life
·~6 days~5 days·
research dosing
·Research literature cites 1–12 mg weekly subcutaneous in dose-escalation studies.Research literature cites 2.5–15 mg weekly subcutaneous, escalated over 16+ weeks.·
trending
search demand
●95/10088/100○
vendors stocking
○12●
aliases
·LY3437943 · GLP-3 · triple-GMounjaro · Zepbound·
§ 03

Use-case overlap

only retatrutide
  • metabolic dysfunction
  • fatty liver
both
  • weight loss
only tirzepatide
  • type 2 diabetes
§ 04

Where to buy

retatrutide
Retatrutide
1 verified vendor
Limitless Life Nootropics
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tirzepatide
Tirzepatide
2 verified vendors
Amino AsylumLimitless Life Nootropics
See all vendors →
§ 05

Sources

  1. [01]Triple–Hormone-Receptor Agonist Retatrutide for Obesity (NEJM)· Retatrutide
  2. [02]Lilly TRIUMPH Phase 3 announcement· Retatrutide
  3. [03]Tirzepatide once weekly for the treatment of obesity (NEJM)· Tirzepatide
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